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Article

Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcoma

1 Jan 2019

Abstract excerpt

BACKGROUND: While most pediatric sarcomas respond to front-line therapy, some bone sarcomas do not show radiographic response like soft-tissue sarcomas (rhabdomyosarccomas) but do show 90% necrosis. Though, new therapies are urgently needed to improve survival and quality of life in pediatric patients with sarcomas. Complex chromosomal aberrations such as amplifications and deletions of DNA sequences are...

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PMID: 30704460
DOI: 10.1186/s12920-018-0456-5

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