Article
Detection of burst-promoting activity in spleens of myeloproliferative sarcoma virus-infected mice using serum-free cultures.
Acta pathologica japonica - 1 Apr 1991
Matsuo K, Oda H, Fukushima T, Matsuoka J, Hashimoto N, Tadokoro K, Kohama H, Sato M, Jasmin C, Urano Y
Abstract excerpt
Myeloproliferative syndrome was induced in adult DBA/2 mice by inoculation with myeloproliferative sarcoma virus (MPSV) and Friend murine leukemia virus (F-MuLV) as a helper virus. On day 26 after infection, the spleen weighed a maximum of 2.0 g (about 30 times the control weight). Assay of multipotent stem cells in vitro showed that the more enlarged spleens contained an increased number and concentration of...
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