Recombinant human thrombopoietin (TPO) stimulates erythropoiesis by inhibiting erythroid progenitor cell apoptosis.

doi:10.1046/j.1365-2141.1997.1802997.x

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Article

Recombinant human thrombopoietin (TPO) stimulates erythropoiesis by inhibiting erythroid progenitor cell apoptosis.

British journal of haematology - 1 Jul 1997

Ratajczak M Z, Ratajczak J, Marlicz W, Pletcher C H, Machalinski B, Moore J, Hung H, Gewirtz A M

Abstract excerpt

Thrombopoietin (TPO) has been reported to stimulate erythropoiesis, but the stimulatory mechanism has not been defined. To address this issue, we performed serum-free cell-culture experiments with recombinant human TPO and purified human progenitor cells. We found that TPO alone was able to stimulate the megakaryocyte colony formation in serum-free cultures, but erythroid colonies were never observed. Only in the...

Topics

Apoptosis
Cells, Cultured
Culture Media, Serum-Free
Erythroid Precursor Cells
Erythropoiesis
Humans
Interleukin-3
Phenotype
Polymerase Chain Reaction
Thrombopoietin

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PMID: 9233556
DOI: 10.1046/j.1365-2141.1997.1802997.x

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