Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese.

Human molecular genetics - 15 Jun 2008

Mototani Hideyuki, Iida Aritoshi, Nakajima Masahiro, Furuichi Tatsuya, Miyamoto Yoshinari, Tsunoda Tatsuhiko, Sudo Akihiro, Kotani Akihiro, Uchida Atsumasa, Ozaki Kouichi, Tanaka Yoshiya, Nakamura Yusuke, Tanaka Toshihiro, Notoya Kohei, Ikegawa Shiro

Abstract excerpt

Osteoarthritis (OA) is the most common form of arthritis and is characterized by the gradual loss of articular cartilage. Several OA-susceptibility genes have been identified; however, there are few pharmaceutical targets that can be targeted with small-molecule compounds. To investigate whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Molecular Sequence Data

Share to Osteoarthritis, Knee

Share to Promoter Regions, Genetic

Share to Signal Transduction

Share to Synovial Membrane

Source

Identifiers

PMID: 18325907
DOI: 10.1093/hmg/ddn069

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18325907-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese.PMID 18325907Read ↗

Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections.Semantic proximity Read ↗

Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.Semantic proximity Read ↗

Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 gene and risk of knee osteoarthritis in a Chinese Han population.Semantic proximity Read ↗

The genetic epidemiology of osteoarthritis.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.Semantic proximity Read ↗

A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.Semantic proximity Read ↗

Genetics of osteoarthritis.Semantic proximity Read ↗

An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage.Semantic proximity Read ↗

Osteoarthritis year 2011 in review: genetics.Semantic proximity Read ↗

Association between the +104T/C polymorphism in the 5'UTR of GDF5 and susceptibility to knee osteoarthritis: a meta-analysis.Semantic proximity Read ↗

Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis.Semantic proximity Read ↗

Polymorphism of rs6426749 at 1p36.12 is associated with the risk of osteoarthritis in Taiwanese female population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.