Article
Screening for genetic heterogeneity in the interferon sensitivity determining region of the hepatitis C virus genome by polymerase chain reaction with melting curve analysis.
Clinical chemistry and laboratory medicine - 1 Jan 2008
Sasaki Daisuke, Sugahara Kazuyuki, Inokuchi Naoko, Yanagihara Katunori, Hasegawa Hiroo, Mori Sayaka, Yamada Yasuaki, Kamihira Shimeru
Abstract excerpt
BACKGROUND: Although mutations in the interferon (IFN) sensitivity determining region (ISDR) of hepatitis C virus (HCV) have been reported to be useful as a predictive viral factor for IFN therapy in patients infected with HCV-1b, such laboratory research has not been favorably translated into the clinic. To promote such translation, we attempted the establishment of a rapid and simple polymerase chain reaction...
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