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Article

Divergent sodium channel defects in familial hemiplegic migraine

9 Jul 2008

Abstract excerpt

Familial hemiplegic migraine type 3 (FHM3) is a severe autosomal dominant migraine disorder caused by mutations in the voltage-gated sodium channel Na(V)1.1 encoded by SCN1A. We determined the functional consequences of three mutations linked to FHM3 (L263V, Q1489K, and L1649Q) in an effort to identify molecular defects that underlie this inherited migraine disorder. Only L263V and Q1489K generated quantifiable...

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PMID: 18621678
DOI: 10.1073/pnas.0711717105

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