Article

Targeting tumor cell-derived CCL2 as a strategy to overcome bevacizumab resistance in ETV5+ colorectal cancer

2020-04-29

Abstract excerpt

<h4>Background: </h4> ETV5 mediated angiogenesis was dependent on PDGF-BB/PDGFR-β/Src/STAT3/VEGFA pathway in colorectal cancer (CRC) in our previous study. However, whether ETV5 affects effect of antiangiogenic therapy in CRC requires further investigation. Methods GSEA analysis and a series of experiments were performed to identify the critical candidate gene involved in bevacizumab resistance, and further explo...

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Literature Corpus work: a2ac9995-92b5-53fc-b769-3e3724845e66
DOI: 10.21203/rs.3.rs-25020/v1

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