Article
Analysis of near full-length genomic sequences of drug-resistant HIV-1 spreading among therapy-naïve individuals in Nagoya, Japan: amino acid mutations associated with viral replication activity.
AIDS research and human retroviruses - 1 Aug 2008
Ibe Shiro, Shigemi Urara, Sawaki Kaori, Fujisaki Seiichiro, Hattori Junko, Yokomaku Yoshiyuki, Mamiya Naoto, Hamaguchi Motohiro, Kaneda Tsuguhiro
Abstract excerpt
We analyzed a total of 12 near full-length genomes of drug-resistant HIV-1 spreading among therapy-naïve individuals in Nagoya, Japan. Genomes comprised seven protease inhibitor (PI)-resistant viruses possessing an M46I (n = 6) or L90M mutation (n = 1) and five non-nucleoside reverse transcriptase inhibitor-resistant viruses possessing a K103N mutation. All 12 viruses conserved both an H87Q mutation in the...
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