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Effect of separase depletion on ionizing radiation‐induced cell cycle checkpoints and survival in human lung cancer cell lines

8 Jul 2008

Abstract excerpt

OBJECTIVES: This study is to evaluate the effect of separase depletion on cell cycle progression of irradiated and non-irradiated cells through the G(2)/M phases and consecutive cell survival. MATERIALS AND METHODS: Separase was depleted with siRNA in two human non-small cell lung carcinoma (NSCLC) cell lines. Cell cycle progression, mitotic fraction, DNA repair, apoptotic and clonogenic cell death were...

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PMID: 18616699
DOI: 10.1111/j.1365-2184.2008.00540.x

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