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Article

Atrial Natriuretic Peptide Frameshift Mutation in Familial Atrial Fibrillation

9 Jul 2008

Abstract excerpt

Atrial fibrillation is a common arrhythmia that is hereditary in a small subgroup of patients. In a family with 11 clinically affected members, we mapped an atrial fibrillation locus to chromosome 1p36-p35 and identified a heterozygous frameshift mutation in the gene encoding atrial natriuretic peptide. Circulating chimeric atrial natriuretic peptide (ANP) was detected in high concentration in subjects with the...

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Share to Atrial Fibrillation Management and Outcomes
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PMID: 18614783
DOI: 10.1056/nejmoa0706300

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