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Article

Astrocyte responses to injury: VEGF simultaneously modulates cell death and proliferation

10 Jul 2008

Abstract excerpt

Hypoxia is linked to changes in blood-brain barrier (BBB) permeability, and loss of BBB integrity is characteristic of many pathological brain diseases including stroke. In particular, astrocytes play a central role in brain homeostasis and BBB function. We investigated how hypoxia affects astrocyte survival and assessed whether VEGF release through hypoxia-inducible factor-1alpha (HIF-1alpha) induction plays a...

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PMID: 18614764
DOI: 10.1152/ajpregu.00536.2007

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