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Article

The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.

The Journal of clinical investigation - 1 Nov 2009

Weidemann Alexander, Kerdiles Yann M, Knaup Karl X, Rafie Christopher A, Boutin Adam T, Stockmann Christian, Takeda Norihiko, Scadeng Miriam, Shih Andy Y, Haase Volker H, Simon M Celeste, Kleinfeld David, Johnson Randall S

Abstract excerpt

A key adaptation to environmental hypoxia is an increase in erythropoiesis, driven by the hormone erythropoietin (EPO) through what is traditionally thought to be primarily a renal response. However, both neurons and astrocytes (the largest subpopulation of glial cells in the CNS) also express EPO following ischemic injury, and this response is known to ameliorate damage to the brain. To investigate the role of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Deletion

Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

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Identifiers

PMID: 19809162
DOI: 10.1172/JCI39378
PMCID: PMC2769183

Genes

EPO
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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