Article
Simultaneous gain and loss of functions caused by a single amino acid substitution in the beta subunit of Escherichia coli RNA polymerase: suppression of nusA and rho mutations and conditional lethality.
Genetics - 1 Mar 1992
Sparkowski J, Das A
Abstract excerpt
Transcript elongation and termination in Escherichia coli is modulated, in part, by the nusA gene product, an acidic protein that interacts not only with RNA polymerase itself but also with ancillary factors, namely the host termination protein Rho and phage lambda antitermination protein, N. The E. coli nusA1 mutant fails to support lambda development due to a specific defect in N-mediated antitermination....
Topics
- Alleles
- Amino Acids
- Bacterial Proteins
- Base Sequence
- Cloning, Molecular
- DNA, Bacterial
- DNA-Directed RNA Polymerases
- Escherichia coli
- Escherichia coli Proteins
- Genes, Bacterial
- Genes, Dominant