Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia.

1 Jan 2008

Abstract excerpt

OBJECTIVE: Inactivation of the FA-BRCA pathway results in chromosomal instability. Fanconi anaemia (FA) patients have an inherited defect in this pathway and are strongly predisposed to the development of acute myeloid leukaemia (AML). Studies in sporadic cancers have shown promoter methylation of the FANCF gene in a significant proportion of various solid tumours. However, only a single leukaemic case with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18607065
DOI: 10.3233/clo-2008-0426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia.PMID 18607065Read ↗

Deletion and reduced expression of the Fanconi anemia FANCA gene in sporadic acute myeloid leukemia.Semantic proximity Read ↗

Bi-allelic silencing of the Fanconi anaemia gene FANCF in acute myeloid leukaemia.Semantic proximity Read ↗

Spectrum and significance of variants and mutations in the Fanconi anaemia group G gene in children with sporadic acute myeloid leukaemia.Semantic proximity Read ↗

Analysis of the Fanconi anaemia complementation group A gene in acute myeloid leukaemia.Semantic proximity Read ↗

Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers.Semantic proximity Read ↗

Constitutional sequence variation in the Fanconi anaemia group C (FANCC) gene in childhood acute myeloid leukaemia.Semantic proximity Read ↗

BRCA promoter methylation in sporadic versus BRCA germline mutation-related breast cancers.Semantic proximity Read ↗

FANCD2 associated with sporadic breast cancer risk.Semantic proximity Read ↗

Epigenetic inactivation of secreted Frizzled‐related proteins in acute myeloid leukaemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.