Article
Bi-allelic silencing of the Fanconi anaemia gene FANCF in acute myeloid leukaemia.
British journal of haematology - 1 Nov 2003
Tischkowitz Marc, Ameziane Najim, Waisfisz Quinten, De Winter Johan P, Harris Richard, Taniguchi Toshiyasu, D'Andrea Alan, Hodgson Shirley V, Mathew Christopher G, Joenje Hans
Abstract excerpt
Fanconi anaemia (FA) is a chromosomal instability disorder associated with a high risk of acute myeloid leukaemia (AML). Previous work has shown that the AML cell line CHRF-288, derived from a sporadic AML-M7 patient, does not express FANCF protein and exhibits a cellular FA phenotype. We show that this phenotype is corrected by a FANCF-expressing plasmid and that the absence of FANCF protein is explained by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.