Article
Constitutional sequence variation in the Fanconi anaemia group C (FANCC) gene in childhood acute myeloid leukaemia.
British journal of haematology - 1 Apr 2003
Barber Lisa M, McGrath Helen E N, Meyer Stefan, Will Andrew M, Birch Jillian M, Eden Osborn B, Taylor G Malcolm
Abstract excerpt
The extent to which genetic susceptibility contributes to the causation of childhood acute myeloid leukaemia (AML) is not known. The inherited bone marrow failure disorder Fanconi anaemia (FA) carries a substantially increased risk of AML, raising the possibility that constitutional variation in the FA (FANC) genes is involved in the aetiology of childhood AML. We have screened genomic DNA extracted from...
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