Article
Methylation of class II transactivator gene promoter IV is not associated with susceptibility to multiple sclerosis.
BMC medical genetics - 7 Jul 2008
Ramagopalan Sreeram V, Dyment David A, Morrison Katie M, Herrera Blanca M, Deluca Gabriele C, Lincoln Matthew R, Orton Sarah M, Handunnetthi Lahiru, Chao Michael J, Sadovnick A Dessa, Ebers George C
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. The MHC class II transactivator (MHC2TA) is the master controller of expression of class II genes, and methylation of the promoter of this gene has been previously been shown to alter its function. In this study we sought to assess whether or not...
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