Article
Interaction between interleukin-1beta -31T/C gene polymorphism and drinking and smoking habits on the risk of hepatocellular carcinoma among Japanese.
Cancer letters - 18 Nov 2008
Sakamoto Tatsuhiko, Higaki Yasuki, Hara Megumi, Ichiba Masayoshi, Horita Mikako, Mizuta Toshihiko, Eguchi Yuichiro, Yasutake Tsutomu, Ozaki Iwata, Yamamoto Kyosuke, Onohara Shingo, Kawazoe Seiji, Shigematsu Hirohisa, Koizumi Shunzo, Tanaka Keitaro
Abstract excerpt
The risk of hepatocellular carcinoma (HCC) increases with the severity of hepatic inflammation. Interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha are proinflammatory cytokines with multiple biological effects and may play essential roles in inflammation-linked tumor development. We conducted a case-control study including 209 incident HCC cases and two control groups (275 hospital controls and 381...
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