Article
Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.
European heart journal - 1 Sept 2008
van der Net Jeroen B, Oosterveer Daniëlla M, Versmissen Jorie, Defesche Joep C, Yazdanpanah Mojgan, Aouizerat Bradley E, Steyerberg Ewout W, Malloy Mary J, Pullinger Clive R, Kastelein John J P, Kane John P, Sijbrands Eric J G
Abstract excerpt
AIMS: Recent large association studies have revealed associations between genetic polymorphisms and myocardial infarction and coronary heart disease (CHD). We performed a replication study of 10 polymorphisms and CHD in a population with familial hypercholesterolemia (FH), individuals at extreme risk of CHD. METHODS AND RESULTS: We genotyped 10 polymorphisms in 2145 FH patients and studied the association between...
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