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Article

Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia.

BMC medical genetics - 3 Jul 2008

Parimi Neeta, Tromp Gerard, Kuivaniemi Helena, Nien Jyh Kae, Gomez Ricardo, Romero Roberto, Goddard Katrina Ab

Abstract excerpt

BACKGROUND: In utero interactions between incompatible maternal and fetal genotypes are a potential mechanism for the onset or progression of pregnancy related diseases such as pre-eclampsia (PE). However, the optimal analytical approach and study design for evaluating incompatible maternal/offspring genotype combinations is unclear. METHODS: Using simulation, we estimated the type I error and power of...

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PMID: 18598365
DOI: 10.1186/1471-2350-9-60
PMCID: PMC2474585

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