Article
Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations.
Diabetes - 1 Sept 2008
Fawcett Katherine A, Grimsey Neil, Loos Ruth J F, Wheeler Eleanor, Daly Allan, Soos Maria, Semple Robert, Syddall Holly, Cooper Cyrus, Siniossoglou Symeon, O'Rahilly Stephen, Wareham Nicholas J, Barroso Inês
Abstract excerpt
OBJECTIVE: Loss of lipin 1 activity causes lipodystrophy and insulin resistance in the fld mouse, and LPIN1 expression and common genetic variation were recently suggested to influence adiposity and insulin sensitivity in humans. We aimed to conduct a comprehensive association study to clarify the influence of common LPIN1 variation on adiposity and insulin sensitivity in U.K. populations and to examine the role...
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