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Article

Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy.

American heart journal - 1 Jul 2008

Parks Sharie B, Kushner Jessica D, Nauman Deirdre, Burgess Donna, Ludwigsen Susan, Peterson Amanda, Li Duanxiang, Jakobs Petra, Litt Michael, Porter Charles B, Rahko Peter S, Hershberger Ray E

Abstract excerpt

BACKGROUND: Lamin A/C mutations are a well-established cause of dilated cardiomyopathy (DCM), although their frequency has not been examined in a large cohort of patients. We sought to examine the frequency of mutations in LMNA, the gene encoding lamin A/C, in patients with idiopathic (IDC) or familial dilated cardiomyopathy (FDC). METHODS: Clinical cardiovascular data, family histories, and blood samples were...

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Topics

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Share to Cardiomyopathy, Dilated
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Lamin Type A

Share to Mutation, Missense

Share to Nuclear Lamina

Share to Severity of Illness Index

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Source

Open in PubMed Open full text

Identifiers

PMID: 18585512
DOI: 10.1016/j.ahj.2008.01.026
PMCID: PMC2527054

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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