Article
Genetic and phenotypic analysis of dilated cardiomyopathy with conduction system disease: demand for strategies in the management of presymptomatic lamin A/C mutant carriers.
European journal of heart failure - 1 Aug 2006
Perrot Andreas, Sigusch Holger H, Nägele Herbert, Genschel Janine, Lehmkuhl Hans, Hetzer Roland, Geier Christian, Leon Perez Veronica, Reinhard Dirk, Dietz Rainer, Josef Osterziel Karl, Schmidt Hartmut H-J
Abstract excerpt
BACKGROUND: One-third of cases of dilated cardiomyopathy (DCM) is of familial aetiology. Several genes have been reported to cause the autosomal dominant form of DCM. AIMS: To analyze the lamin A/C gene (LMNA) in 31 unrelated patients with DCM and conduction system disease (CSD). METHODS: Patients and family members underwent physical examination, ECG/Holter-ECG, echocardiography, and selective coronary...
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