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Article

Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer.

The Journal of biological chemistry - 16 Nov 2007

Kimura Momoko, Yamamoto Tae, Zhang Jianyong, Itoh Ken, Kyo Motoki, Kamiya Terue, Aburatani Hiroyuki, Katsuoka Fumiki, Kurokawa Hirofumi, Tanaka Toshiyuki, Motohashi Hozumi, Yamamoto Masayuki

Abstract excerpt

Nrf2-small Maf heterodimer activates the transcription of many cytoprotective genes through the antioxidant response element and serves as a key factor in xenobiotic and oxidative stress responses. Our surface plasmon resonance-microarray binding analysis revealed that both Nrf2-MafG heterodimer and MafG homodimer bind to the consensus Maf recognition element with high affinity but bind differentially to the...

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PMID: 17875642
DOI: 10.1074/jbc.M706863200

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