Article
Hepatitis E virus replication in human intestinal cells.
Gut - 1 May 2020
Marion Olivier, Lhomme Sebastien, Nayrac Manon, Dubois Martine, Pucelle Mélanie, Requena Mary, Migueres Marion, Abravanel Florence, Peron Jean Marie, Carrere Nicolas, Suc Bertrand, Delobel Pierre, Kamar Nassim, Izopet Jacques
Abstract excerpt
OBJECTIVE: Hepatitis E virus (HEV), one of the most common agent of acute hepatitis worldwide, is mainly transmitted enterically, via contaminated water for HEV genotypes 1 (HEV1) and HEV2, or by eating raw or undercooked infected meat for HEV genotype 3 (HEV3) and HEV4. However, little is known about how the ingested HEV reaches the liver or its ability to replicate in intestinal cells. DESIGN: We developed...
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