Microsatellites that violate Chargaff's second parity rule have base order-dependent asymmetries in the folding energies of complementary DNA strands and may not drive speciation.

Abstract excerpt

Models for meiotic recombination based on Crick's "unpairing postulate" require symmetrical extrusion of stem-loop structures from homologous DNA duplexes. The potential for such extrusion is abundant in many species and, for a given single-strand segment, can be quantitated as the "folding of natural sequence" (FONS) energy value. This, in turn, can be decomposed into base order-dependent and base...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA, Complementary
• Share to Evolution, Molecular