Article
Chargaff's second parity rule lies at the origin of additive genetic interactions in quantitative traits to make omnigenic selection possible.
PeerJ - 1 Jan 2023
Matkarimov Bakhyt T, Saparbaev Murat K
Abstract excerpt
Background: Francis Crick's central dogma provides a residue-by-residue mechanistic explanation of the flow of genetic information in living systems. However, this principle may not be sufficient for explaining how random mutations cause continuous variation of quantitative highly polygenic complex traits. Chargaff's second parity rule (CSPR), also referred to as intrastrand DNA symmetry, defined as near-exact...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.