Article
Chargaff's legacy.
Gene - 30 Dec 2000
Forsdyke D R, Mortimer J R
Abstract excerpt
Of Chargaff's four rules on DNA base composition, only his first parity rule was incorporated into mainstream biology as the DNA double helix. Now, the cluster rule, the second parity rule, and the GC rule, reveal the multiple levels of information in our genomes and potential conflicts between them. In these terms we can understand how double-stranded RNA became an intracellular alarm signal, how potentially...
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