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Article

Differential expression of GADD45β in normal and osteoarthritic cartilage: Potential role in homeostasis of articular chondrocytes

24 Jun 2008

Abstract excerpt

OBJECTIVE: Our previous study suggested that growth arrest and DNA damage-inducible protein 45beta (GADD45beta) prolonged the survival of hypertrophic chondrocytes in the developing mouse embryo. This study was undertaken, therefore, to investigate whether GADD45beta plays a role in adult articular cartilage. METHODS: Gene expression profiles of cartilage from patients with late-stage osteoarthritis (OA) were...

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PMID: 18576389
DOI: 10.1002/art.23504

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