The alpha1L-adrenoceptor is an alternative phenotype of the alpha1A-adrenoceptor.

Abstract excerpt

Despite over two decades of research, the molecular identity of the alpha1L-adrenoceptor phenotype has remained elusive. In this issue of the BJP, Gray et al. (2008) provide persuasive evidence that the in vivo alpha1L-adrenoceptor phenotype requires the expression of the alpha1A-adrenoceptor gene. They have shown that in mice lacking the functional alpha1A-adrenoceptor gene, alpha1L-mediated responses to...

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