Article
Light-dependent regulation of structural flexibility in a photochromic fluorescent protein.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2008
Mizuno Hideaki, Mal Tapas Kumar, Wälchli Markus, Kikuchi Akihiro, Fukano Takashi, Ando Ryoko, Jeyakanthan Jeyaraman, Taka Junichiro, Shiro Yoshitsugu, Ikura Mitsuhiko, Miyawaki Atsushi
Abstract excerpt
The structural basis for the photochromism in the fluorescent protein Dronpa is poorly understood, because the crystal structures of the bright state of the protein did not provide an answer to the mechanism of the photochromism, and structural determination of the dark state has been elusive. We performed NMR analyses of Dronpa in solution at ambient temperatures to find structural flexibility of the protein in...
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