Article
Association of functionally important polymorphisms in cytochrome P4501B1 with lung cancer.
Mutation research - 25 Aug 2008
Shah Parag P, Singh Arvind P, Singh Madhu, Mathur Neeraj, Mishra Bhartendu N, Pant Mohan C, Parmar Devendra
Abstract excerpt
In the present study, genotype and haplotype frequencies of four polymorphisms of cytochrome P450 1B1 (CYP1B1) that cause amino acid changes (Arg-Gly at codon 48, Ala-Ser at codon 119, Leu-Val at 432 and Asn-Ser at codon 453) were studied in 200 patients suffering from lung cancer and equal number of controls. A significant difference was observed for the distribution of variant genotypes of CYP1B1Arg48Gly and...
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