Article
Pathogenic ATM mutations occur rarely in a subset of multiple myeloma patients.
British journal of haematology - 1 Sept 2008
Austen Belinda, Barone Giancarlo, Reiman Anne, Byrd Philip J, Baker Claire, Starczynski Jane, Nobbs Michael C, Murphy Raymond P, Enright Helen, Chaila Elijah, Quinn John, Stankovic Tatjana, Pratt Guy, Taylor A Malcolm R
Abstract excerpt
Ataxia Telangiectasia (A-T) patients have biallelic inactivation of the ATM gene and exhibit a 200-fold-increased frequency of lymphoid tumours. ATM mutations have been found in a number of adult lymphoid malignancies but there is no data on the occurrence of ATM mutations in multiple myeloma tumours. The purpose of our work was to investigate the occurrence of ATM mutations in multiple myeloma and to this end we...
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