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Article

Multiplex Kinase Signaling Modifies Cardiac Function at the Level of Sarcomeric Proteins

21 Jun 2008

Abstract excerpt

The transient change in tension development and length in a working cardiac myocyte during the heart beat reflects the integrated effects of kinases in signaling cascades regulating mechanisms controlling the dynamics and intensity of a transient increase in cytoplasmic Ca2+ as well as the responsiveness of the sarcomeres to Ca2+. Kinases modifying regulatory membrane proteins represent a major mechanism for...

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PMID: 18567577
DOI: 10.1074/jbc.r800037200

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