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Article

MEK1/2 induces STAT5-mediated germline transcription of the TCRgamma locus in response to IL-7R signaling.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2008

Maki Kazushige, Ikuta Koichi

Abstract excerpt

The IL-7R plays an essential role in gammadelta T cell development by inducing V-J recombination of the TCRgamma locus through STAT5. Although tyrosine residues in the intracellular domain of the mouse IL-7R alpha-chain (IL-7Ralpha) have been implicated in STAT5 activation, it is still unknown whether they are essential for gammadelta T cell development. In this study, we showed that those IL-7Ralpha tyrosine...

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Source

Identifiers

PMID: 18566415
DOI: 10.4049/jimmunol.181.1.494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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