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Article

Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A

19 Jun 2008

Abstract excerpt

Previous studies showed that Fanconi anemia (FA) murine stem cells have defective reconstitution after bone marrow (BM) transplantation. The mechanism underlying this defect is not known. Here, we report defective homing of FA patient BM progenitors transplanted into mouse models. Using cells from patients carrying mutations in FA complementation group A (FA-A), we show that when transplanted into nonobese...

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PMID: 18565850
DOI: 10.1182/blood-2008-03-147090

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