Article
Combined intramyocardial delivery of human pericytes and cardiac stem cells additively improves the healing of mouse infarcted hearts through stimulation of vascular and muscular repair.
Circulation research - 8 May 2015
Avolio Elisa, Meloni Marco, Spencer Helen L, Riu Federica, Katare Rajesh, Mangialardi Giuseppe, Oikawa Atsuhiko, Rodriguez-Arabaolaza Iker, Dang Zexu, Mitchell Kathryn, Reni Carlotta, Alvino Valeria V, Rowlinson Jonathan, Livi Ugolini, Cesselli Daniela, Angelini Gianni, Emanueli Costanza, Beltrami Antonio P, Madeddu Paolo
Abstract excerpt
RATIONALE: Optimization of cell therapy for cardiac repair may require the association of different cell populations with complementary activities. OBJECTIVE: Compare the reparative potential of saphenous vein-derived pericytes (SVPs) with that of cardiac stem cells (CSCs) in a model of myocardial infarction, and investigate whether combined cell transplantation provides further improvements. METHODS AND RESULTS:...
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