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Article

Genetic variation in the renin-angiotensin system modifies the beneficial effects of ACE inhibitors on the risk of diabetes mellitus among hypertensives.

Journal of human hypertension - 1 Nov 2008

Bozkurt O, Verschuren W M M, van Wieren-de Wijer B M A, Knol M J, de Boer A, Grobbee D E, Geerlings M I, Heerdink E R, Klungel O H

Abstract excerpt

The aim of this study was to assess whether the association between angiotensin-converting enzyme (ACE) inhibitor use and the incidence of treated diabetes mellitus is modified by genetic polymorphisms in the renin-angiotensin system (RAS).In a nested case-control study, treated hypertensive patients were genotyped for ACE (insertion (I)/deletion (D)), angiotensinogen (AGT; M235T) and angiotensin II type 1...

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Source

Identifiers

PMID: 18563171
DOI: 10.1038/jhh.2008.62

Genes

ACE
AGTR1
AGT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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