Article
Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2008
Chang Jeffrey S, Yeh Ru-Fang, Wiencke John K, Wiemels Joseph L, Smirnov Ivan, Pico Alexander R, Tihan Tarik, Patoka Joe, Miike Rei, Sison Jennette D, Rice Terri, Wrensch Margaret R
Abstract excerpt
Glioma is a complex disease that is unlikely to result from the effect of a single gene. Genetic analysis at the pathway level involving multiple genes may be more likely to capture gene-disease associations than analyzing genes one at a time. The current pilot study included 112 Caucasians with glioblastoma multiforme and 112 Caucasian healthy controls frequency matched to cases by age and gender. Subjects were...
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