Article
Effects of in utero and childhood tobacco smoke exposure and beta2-adrenergic receptor genotype on childhood asthma and wheezing.
Pediatrics - 1 Jul 2008
Wang Chengwei, Salam Muhammad T, Islam Talat, Wenten Madé, Gauderman W James, Gilliland Frank D
Abstract excerpt
OBJECTIVE: Associations between single-nucleotide polymorphisms in the beta2-adrenergic receptor gene and asthma and wheeze have been inconsistent. Recent studies indicated that tobacco smoke affects beta2-adrenergic receptor gene expression and associations of beta2-adrenergic receptor gene variants with asthma in adults. We aimed to investigate the joint effects of in utero and childhood secondhand tobacco...
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