Article
Mild processing defect of porcine DeltaF508-CFTR suggests that DeltaF508 pigs may not develop cystic fibrosis disease.
Biochemical and biophysical research communications - 15 Aug 2008
Liu Yanli, Wang Ying, Jiang Yong, Zhu Na, Liang Haitao, Xu Lina, Feng Xuechao, Yang Hong, Ma Tonghui
Abstract excerpt
Recent efforts have made significant progress in generating transgenic pigs with the DeltaF508-CFTR mutation to model the lung and pancreatic disease of human cystic fibrosis. However, species differences in the processing and function of human, pig and mouse DeltaF508-CFTR reported recently raise concerns about the phenotypic consequence of the gene-targeted pig model. The purpose of the present study was to...
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