Article
Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2022
Yu Wenjie, Moninger Thomas O, Thurman Andrew L, Xie Yuliang, Jain Akansha, Zarei Keyan, Powers Linda S, Pezzulo Alejandro A, Stoltz David A, Welsh Michael J
Abstract excerpt
Submucosal glands (SMGs) protect lungs but can also contribute to disease. For example, in cystic fibrosis (CF), SMGs produce abnormal mucus that disrupts mucociliary transport. CF is an ion transport disease, yet knowledge of the ion transporters expressed by SMG acini, which produce mucus, and SMG ducts that carry it to the airway lumen is limited. Therefore, we isolated SMGs from newborn pigs and used...
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