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In silico transcriptomic mapping of integrins and immune activation in Basal-like and HER2+ breast cancer

19 Jan 2021

Abstract excerpt

PURPOSE: Integrins, transmembrane receptors that mediate cell-extracellular matrix and cell-cell interactions, have been linked to several cancer-associated features. A less explored function of integrins in cancer is their role in leukocyte homing and activation. Understanding their relationship with immune cell infiltrates and immune checkpoints is an area of interest in cancer research. METHODS: The expression...

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PMID: 33469836
DOI: 10.1007/s13402-020-00583-9

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