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Article

Functional polymorphisms of the FAS gene associated with risk of vitiligo in Chinese populations: a case-control analysis.

The Journal of investigative dermatology - 1 Dec 2008

Li Miao, Sun Dongjie, Li Chunying, Zhang Zhengdong, Gao Lin, Li Kai, Li Hong, Gao Tianwen

Abstract excerpt

The FAS/FASLG system plays a key role in regulating apoptosis. Previous findings have shown that CD4-dependent destruction of melanocytes is partially inhibited by blocking FAS-FASLG interactions in autoimmune vitiligo. Functional polymorphisms of the FAS and FASLG genes can alter their transcriptional activities. In a hospital-based case-control study of 750 vitiligo patients and 756 controls, we genotyped the...

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Source

Identifiers

PMID: 18548110
DOI: 10.1038/jid.2008.161

Genes

FAS
FASLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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