Article
Effect of Efalizumab on neutrophil and monocyte functions in patients with psoriasis.
International journal of immunopathology and pharmacology - 1 Jan 2000
Capsoni F, Ongari A M, Frigerio E, Taglioni M, Altomare G F
Abstract excerpt
We evaluated the effect of efalizumab on neutrophil and monocyte functions. The in vitro pre-incubation with efalizumab concentrations similar to those reached during in vivo therapy almost completely saturated CD11a binding sites without affecting the membrane expression of CD11b, CD128a or CD128b. There was a significant reduction in the chemotactic activity of the pre-treated cells toward three different...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.