Article
Phenotypic changes in neutrophils related to anti-inflammatory therapy.
Biochimica et biophysica acta - 3 Jan 2000
Barton A E, Bayley D L, Mikami M, Llewellyn-Jones C G, Stockley R A
Abstract excerpt
Previous work from the group has shown that non-steroidal anti-inflammatory agents given to volunteers and patients inhibit PMN function possibly by affecting the developing neutrophil during the differentiation process. In this study indomethacin treatment in vivo reduced neutrophil chemotaxis and proteolytic degradation of fibronectin, with a maximal effect after 14 days. Stimulated neutrophil adherence to...
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