Article
High VEGF serum values are associated with locoregional spread of gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
Molecular and cellular endocrinology - 15 Apr 2016
Cigrovski Berković Maja, Čačev Tamara, Catela Ivković Tina, Marout Jasminka, Ulamec Monika, Zjačić-Rotkvić Vanja, Kapitanović Sanja
Abstract excerpt
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are highly vascularized neoplasms, capable of synthethisizing VEGF-A, a key mediator of angiogenesis. In pancreatic neuroendocrine tumors (pNETs) VEGF expression is higher in benign and low-grade tumors and associated with good prognosis (neuroendocrine paradox) while the VEGF role in gastrointestinal NETs (GI-NETs) is still unclear. In this study, we...
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