Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth.

Experimental and molecular pathology - 1 Jun 2008

Qiu Ying, Morii Eiichi, Zhang Binglin, Tomita Yasuhiko, Aozasa Katsuyuki

Abstract excerpt

Enhanced expression of valosin-containing protein (VCP) correlates with invasiveness and metastatic potential of cancer cells; therefore its transcriptional regulation could be a new target for cancer therapy. Here, the mechanism for transactivation of VCP promoter by E74-like factor 2 (ELF2), a transcription factor which enhances VCP transcription, was investigated. There was a highly conserved region among...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Chromatin Immunoprecipitation

Share to Gene Expression Regulation, Neoplastic

Share to Promoter Regions, Genetic

Share to Transcriptional Activation

Share to Valosin Containing Protein

Source

Identifiers

PMID: 18544453
DOI: 10.1016/j.yexmp.2008.04.004

Genes

ELF2
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth.PMID 18544453Read ↗

E26 transformation-specific variant 4 as a tumor promotor in human cancers through specific molecular mechanismsSemantic proximity Read ↗

A comprehensive assessment of VCAN transcriptional expression and evaluation as an effective prognostic biomarker against breast cancer: in silico studySemantic proximity Read ↗

The E5 proteins.Semantic proximity Read ↗

[The enhancement of DNA binding ability of a mutated E2 (A338V) protein of HPV-2].Semantic proximity Read ↗

EVL (Ena/VASP-like) expression is up-regulated in human breast cancer and its relative expression level is correlated with clinical stagesSemantic proximity Read ↗

MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer CellsSemantic proximity Read ↗

Structural and Quantitative Expression Analyses of HERV Gene Family in Human TissuesSemantic proximity Read ↗

Feedback Mechanisms Regulate Ets Variant 2 (Etv2) Gene Expression and Hematoendothelial LineagesSemantic proximity Read ↗

A conserved loop in the catalytic domain of eukaryotic elongation factor 2 kinase plays a key role in its substrate specificity.Semantic proximity Read ↗

Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells.Semantic proximity Read ↗

Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes.Semantic proximity Read ↗

Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.