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On the possible origins of DNA damage in human spermatozoa

31 Jul 2009

Abstract excerpt

DNA damage in the male germ line has been linked with a variety of adverse clinical outcomes including impaired fertility, an increased incidence of miscarriage and an enhanced risk of disease in the offspring. The origins of this DNA damage could, in principle, involve: (i) abortive apoptosis initiated post meiotically when the ability to drive this process to completion is in decline (ii) unresolved strand...

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PMID: 19648152
DOI: 10.1093/molehr/gap059

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