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DNA fragmentation in spermatozoa: a historical review

1 Jul 2017

Abstract excerpt

Sperm DNA Fragmentation has been extensively studied for more than a decade. In the 1940s the uniqueness of the spermatozoa protein complex which stabilizes the DNA was discovered. In the fifties and sixties, the association between unstable chromatin structure and subfertility was investigated. In the seventies, the impact of induced DNA damage was investigated. In the 1980s the concept of sperm DNA...

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PMID: 28718529
DOI: 10.1111/andr.12381

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